Wnt/β-Catenin Signaling Activation beyond Robust Nuclear β-Catenin Accumulation in Nondysplastic Barrett’s Esophagus: Regulation via Dickkopf-1

Wnt/β-Catenin Signaling Activation beyond Robust Nuclear β-Catenin Accumulation in Nondysplastic Barrett’s Esophagus: Regulation via Dickkopf-1

INTRODUCTION: Wnt/β-catenin signaling activation has been reported only during the late steps of Barrett’s esophagus (BE) neoplastic progression, but not in BE metaplasia, based on the absence of nuclear β-catenin. However, β-catenin transcriptional activity has been recorded in absence of robust nu...

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Bibliographic Details
Main Authors: Orestis Lyros, Parvaneh Rafiee, Linghui Nie, Rituparna Medda, Nebojsa Jovanovic, Mary F. Otterson, Behnaz Behmaram, Ιnes Gockel, Alexander Mackinnon, Reza Shaker
Format: Article
Language:English
Published: Elsevier 2015-07-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558615000871

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http://www.sciencedirect.com/science/article/pii/S1476558615000871

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