Virtual Screening and Hit Selection of Natural Compounds as Acetylcholinesterase Inhibitors

Virtual Screening and Hit Selection of Natural Compounds as Acetylcholinesterase Inhibitors

Acetylcholinesterase (AChE) is one of the classical targets in the treatment of Alzheimer’s disease (AD). Inhibition of AChE slows down the hydrolysis of acetycholine and increases choline levels, improving the cognitive function. The achieved success of plant-based natural drugs acting as AChE inhi...

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Bibliographic Details
Main Authors: Mariyana Atanasova, Ivan Dimitrov, Stefan Ivanov, Borislav Georgiev, Strahil Berkov, Dimitrina Zheleva-Dimitrova, Irini Doytchinova
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Molecules
Subjects:
acetylcholinesterase (AChE)
natural compounds
virtual screening
molecular docking
molecular dynamins
Alzheimer’s disease (AD)
Online Access:https://www.mdpi.com/1420-3049/27/10/3139

Internet

https://www.mdpi.com/1420-3049/27/10/3139

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