Proteomic Investigation of the Antibacterial Mechanism of Cefiderocol against Escherichia coli

Proteomic Investigation of the Antibacterial Mechanism of Cefiderocol against Escherichia coli

ABSTRACT This study aimed to investigate the antibacterial mechanism of cefiderocol (CFDC) using data-independent acquisition quantitative proteomics combined with cellular and molecular biological assays. Numerous differentially expressed proteins related to the production of NADH, reduced cofactor...

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Bibliographic Details
Main Authors: Gao-Fei Du, Yu Dong, Xiaolu Fan, Ankang Yin, Yao-Jin Le, Xiao-Yan Yang
Format: Article
Language:English
Published: American Society for Microbiology 2022-10-01
Series:Microbiology Spectrum
Subjects:
cefiderocol
E. coli
ROS
NADH
iron ions
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01093-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.01093-22

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