Killer Ig-Like Receptors (KIRs): Their Role in NK Cell Modulation and Developments Leading to Their Clinical Exploitation

Killer Ig-Like Receptors (KIRs): Their Role in NK Cell Modulation and Developments Leading to Their Clinical Exploitation

Natural killer (NK) cells contribute to the first line of defense against viruses and to the control of tumor growth and metastasis spread. The discovery of HLA class I specific inhibitory receptors, primarily of killer Ig-like receptors (KIRs), and of activating receptors has been fundamental to un...

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Bibliographic Details
Main Authors: Daniela Pende, Michela Falco, Massimo Vitale, Claudia Cantoni, Chiara Vitale, Enrico Munari, Alice Bertaina, Francesca Moretta, Genny Del Zotto, Gabriella Pietra, Maria Cristina Mingari, Franco Locatelli, Lorenzo Moretta
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
HLA class I
killer immunoglobulin-like receptors
KIR ligands
inhibitory checkpoints
NK alloreactivity
NK cell education
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01179/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01179/full

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