Unraveling the functional consequences of a novel germline missense mutation (R38C) in the yeast model of succinate dehydrogenase subunit B: insights into neurodegenerative disorders

Unraveling the functional consequences of a novel germline missense mutation (R38C) in the yeast model of succinate dehydrogenase subunit B: insights into neurodegenerative disorders

This study explores the implications of a novel germline missense mutation (R38C) in the succinate dehydrogenase (SDH) subunit B, which has been linked to neurodegenerative diseases. The mutation was identified from the SDH mutation database and corresponds to the SDH2R32C allele, mirroring the huma...

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Bibliographic Details
Main Authors: Jiatong Zheng, Siru Liu, Dongdong Wang, Linlin Li, Surendra Sarsaiya, Hua Zhou, Heng Cai
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Saccharomyces cerevisiae
succinate dehydrogenase
R32C
qRT-PCR
GC-MS
hydrogen peroxide stress
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1246842/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2023.1246842/full

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