Identification of germline population variants misclassified as cancer-associated somatic variants

IntroductionDatabases used for clinical interpretation in oncology rely on genetic data derived primarily from patients of European ancestry, leading to biases in cancer genetics research and clinical practice. One practical issue that arises in this context is the potential misclassification of mul...

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Bibliographic Details
Main Authors: Rebecca D. Pollard, Matthew D. Wilkerson, Padma Sheila Rajagopal
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Medicine
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2024.1361317/full