Shared IVIVR for Five Commercial Enabling Formulations Using the BiPHa+ Biphasic Dissolution Assay

Shared IVIVR for Five Commercial Enabling Formulations Using the BiPHa+ Biphasic Dissolution Assay

The present study intended to confirm the in vivo relevance of the BiPHa+ biphasic dissolution assay using a single set of assay parameters. Herein, we evaluated five commercial drug products formulated by various enabling formulation principles under fasted conditions using the BiPHa+ assay. The in...

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Bibliographic Details
Main Authors: Alexander Denninger, Ulrich Westedt, Karl G. Wagner
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Pharmaceutics
Subjects:
biphasic dissolution
poorly soluble drugs
enabling formulation
IVIVR
biopharmaceutics
drug product development
Online Access:https://www.mdpi.com/1999-4923/13/2/285

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https://www.mdpi.com/1999-4923/13/2/285

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