Impaired insulin signaling at the bladder mucosa facilitates metabolic syndrome-associated bladder overactivity in rats with maternal and post-weaning fructose exposure

Impaired insulin signaling at the bladder mucosa facilitates metabolic syndrome-associated bladder overactivity in rats with maternal and post-weaning fructose exposure

Background/purpose: Metabolic syndrome (MetS) and overactive bladder might share common pathophysiologies. Environmental fructose exposure during pre- and postnatal periods of rats may program MetS-associated bladder overactivity. We explored the dysregulated insulin signalling at bladder mucosa, as...

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Bibliographic Details
Main Authors: Wei-Chia Lee, Kay L.H. Wu, You-Lin Tain, Steve Leu, Yuan-Tso Cheng, Julie Y.H. Chan
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Journal of the Formosan Medical Association
Subjects:
Developmental programming
Endothelial nitric oxide synthase
Insulin resistance
Metabolic syndrome
Nutrient sensing
Overactive bladder
Online Access:http://www.sciencedirect.com/science/article/pii/S0929664622003631

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http://www.sciencedirect.com/science/article/pii/S0929664622003631

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