Prion protein deficiency impairs hematopoietic stem cell determination and sensitizes myeloid progenitors to irradiation
Highly conserved among species and expressed in various types of cells, numerous roles have been attributed to the cellular prion protein (PrPC). In hematopoiesis, PrPC regulates hematopoietic stem cell self-renewal but the mechanisms involved in this regulation are unknown. Here we show that PrPC r...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Ferrata Storti Foundation
2020-05-01
|
| Series: | Haematologica |
| Online Access: | https://haematologica.org/article/view/9377 |