Cardiac involvement in patient-specific induced pluripotent stem cells of myotonic dystrophy type 1: unveiling the impact of voltage-gated sodium channels

Cardiac involvement in patient-specific induced pluripotent stem cells of myotonic dystrophy type 1: unveiling the impact of voltage-gated sodium channels

Myotonic dystrophy type 1 (DM1) is a genetic disorder that causes muscle weakness and myotonia. In DM1 patients, cardiac electrical manifestations include conduction defects and atrial fibrillation. DM1 results in the expansion of a CTG transcribed into CUG-containing transcripts that accumulate in...

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Bibliographic Details
Main Authors: Marion Pierre, Mohammed Djemai, Charles-Albert Chapotte-Baldacci, Valérie Pouliot, Jack Puymirat, Mohamed Boutjdir, Mohamed Chahine
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Physiology
Subjects:
myotonic dystrophy type 1
atrial hiPSC-CMs
ventricular hiPSC-CMs
NaV1.5
optical mapping
cardiac arrhythmias
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2023.1258318/full

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https://www.frontiersin.org/articles/10.3389/fphys.2023.1258318/full

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