Transcriptomic analysis of human sensory neurons in painful diabetic neuropathy reveals inflammation and neuronal loss

Transcriptomic analysis of human sensory neurons in painful diabetic neuropathy reveals inflammation and neuronal loss

Abstract Pathological sensations caused by peripheral painful neuropathy occurring in Type 2 diabetes mellitus (T2DM) are often described as ‘sharp’ and ‘burning’ and are commonly spontaneous in origin. Proposed etiologies implicate dysfunction of nociceptive sensory neurons in dorsal root ganglia (...

Full description

Bibliographic Details
Main Authors: Bradford E. Hall, Emma Macdonald, Margaret Cassidy, Sijung Yun, Matthew R. Sapio, Pradipta Ray, Megan Doty, Pranavi Nara, Michael D. Burton, Stephanie Shiers, Abhik Ray-Chaudhury, Andrew J. Mannes, Theodore J. Price, Michael J. Iadarola, Ashok B. Kulkarni
Format: Article
Language:English
Published: Nature Portfolio 2022-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-08100-8

Internet

https://doi.org/10.1038/s41598-022-08100-8

Similar Items