Perlecan and the Blood-Brain Barrier: Beneficial Proteolysis?

The cerebral microvasculature is important for maintaining brain homeostasis. This is achieved via the blood-brain barrier (BBB), composed of endothelial cells with specialized tight junctions, astrocytes and a basement membrane. Prominent components of the basement membrane extracellular matrix (...

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Bibliographic Details
Main Authors: Jill eRoberts, Michael P. Kahle, Gregory J. Bix
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-08-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00155/full