Human Cytomegalovirus and Human Herpesvirus 6 Coinfection of Dermal Fibroblasts Enhances the Pro-Inflammatory Pathway Predisposing to Fibrosis: The Possible Impact on Systemic Sclerosis

Human Cytomegalovirus and Human Herpesvirus 6 Coinfection of Dermal Fibroblasts Enhances the Pro-Inflammatory Pathway Predisposing to Fibrosis: The Possible Impact on Systemic Sclerosis

Systemic sclerosis (SSc) is a severe autoimmune disease likely triggered by genetic and environmental factors, including viral infections. Human cytomegalovirus (HCMV) and human herpesvirus 6A species (HHV-6A) have been associated with SSc, based on in vivo and in vitro evidence, but the data are st...

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Bibliographic Details
Main Authors: Irene Soffritti, Maria D’Accolti, Clara Maccari, Francesca Bini, Eleonora Mazziga, Flora de Conto, Adriana Calderaro, Maria-Cristina Arcangeletti, Elisabetta Caselli
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Microorganisms
Subjects:
systemic sclerosis
tissue fibrosis factors
HCMV
HHV-6
Online Access:https://www.mdpi.com/2076-2607/10/8/1600

Internet

https://www.mdpi.com/2076-2607/10/8/1600

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