The Role of Tau Pathology in Alzheimer’s Disease and Down Syndrome

<b>Background</b>: Individuals with Down syndrome (DS) exhibit an almost complete penetrance of Alzheimer’s disease (AD) pathology but are underrepresented in clinical trials for AD. The Tau protein is associated with microtubule function in the neuron and is crucial for normal axonal tr...

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Bibliographic Details
Main Authors: Ann-Charlotte Granholm, Eric D. Hamlett
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Journal of Clinical Medicine
Subjects:
Online Access:https://www.mdpi.com/2077-0383/13/5/1338