Modulation of mTOR and CREB pathways following mGluR5 blockade contribute to improved Huntington’s pathology in zQ175 mice

Modulation of mTOR and CREB pathways following mGluR5 blockade contribute to improved Huntington’s pathology in zQ175 mice

Abstract Huntington’s disease (HD) is a neurodegenerative disorder caused by a genetic abnormality in the huntingtin gene that leads to a polyglutamine repeat expansion of the huntingtin protein. The cleaved polyglutamine expansion of mutant huntingtin (mHTT) protein can form aggregates strongly cor...

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Bibliographic Details
Main Authors: Khaled S. Abd-Elrahman, Stephen S. G. Ferguson
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Molecular Brain
Subjects:
mGluR5
Huntington’s disease
zQ175
mHTT
CTEP
ULK1
Online Access:http://link.springer.com/article/10.1186/s13041-019-0456-1

Internet

http://link.springer.com/article/10.1186/s13041-019-0456-1

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