Rebalancing TGF‐β/Smad7 signaling via Compound kushen injection in hepatic stellate cells protects against liver fibrosis and hepatocarcinogenesis

Rebalancing TGF‐β/Smad7 signaling via Compound kushen injection in hepatic stellate cells protects against liver fibrosis and hepatocarcinogenesis

Abstract Background Liver fibrosis and fibrosis‐related hepatocarcinogenesis are a rising cause for morbidity and death worldwide. Although transforming growth factor‐β (TGF‐β) is a critical mediator of chronic liver fibrosis, targeting TGF‐β isoforms and receptors lead to unacceptable side effect....

Full description

Bibliographic Details
Main Authors: Yang Yang, Mayu Sun, Weida Li, Chaobao Liu, Zheshun Jiang, Pengfei Gu, Jingquan Li, Wei Wang, Rongli You, Qian Ba, Xiaoguang Li, Hui Wang
Format: Article
Language:English
Published: Wiley 2021-07-01
Series:Clinical and Translational Medicine
Subjects:
Compound kushen injection
hepatocellular carcinoma
liver fibrosis
TGF‐β/Smad signaling
traditional chinese medicine
Online Access:https://doi.org/10.1002/ctm2.410

Internet

https://doi.org/10.1002/ctm2.410

Similar Items