Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain

Interactions among spinal dorsal horn neurons and microglia contribute to the induction and maintenance of neuropathic pain after peripheral nerve injury. The authors show that depletion of macrophages in the dorsal root ganglia prevents and reverses ongoing nerve injury-induced hypersensitivity.

Bibliographic Details
Main Authors: Xiaobing Yu, Hongju Liu, Katherine A. Hamel, Maelig G. Morvan, Stephen Yu, Jacqueline Leff, Zhonghui Guan, Joao M. Braz, Allan I. Basbaum
Format: Article
Language:English
Published: Nature Portfolio 2020-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13839-2