Leucinostatins target Plasmodium mitochondria to block malaria transmission

Leucinostatins target Plasmodium mitochondria to block malaria transmission

Abstract Background Malaria remains a critical disease. Leucinostatins from the fungus Purpureocillium lilacinum inhibited the transmission of Plasmodium falciparum to mosquitoes via contact. Methods Here, we modified the leucinostatin B (LB) C-terminus to make derivatives and examined their inhibit...

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Bibliographic Details
Main Authors: Guodong Niu, Xiaohong Wang, Jun Li
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Parasites & Vectors
Subjects:
Malaria
Leucinostatin
Transmission-blocking
Mitochondria
MOA
Molecular mechanism
Online Access:https://doi.org/10.1186/s13071-024-06608-8

Internet

https://doi.org/10.1186/s13071-024-06608-8

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