Cytogenomic Profile of Uterine Leiomyoma: In Vivo vs. In Vitro Comparison

Cytogenomic Profile of Uterine Leiomyoma: In Vivo vs. In Vitro Comparison

We performed a comparative cytogenomic analysis of cultured and uncultured uterine leiomyoma (UL) samples. The experimental approach included karyotyping, aCGH, verification of the detected chromosomal abnormalities by metaphase and interphase FISH, <i>MED12</i> mutation analysis and tel...

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Main Authors: Alla S. Koltsova, Olga A. Efimova, Olga V. Malysheva, Natalia S. Osinovskaya, Thomas Liehr, Ahmed Al-Rikabi, Natalia Yu. Shved, Iskender Yu. Sultanov, Olga G. Chiryaeva, Maria I. Yarmolinskaya, Nikolai I. Polenov, Vladislava V. Kunitsa, Maka I. Kakhiani, Tatyana G. Tral, Gulrukhsor Kh. Tolibova, Olesya N. Bespalova, Igor Yu. Kogan, Andrey S. Glotov, Vladislav S. Baranov, Anna A. Pendina
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Biomedicines
Subjects:
uterine leiomyoma
abnormal karyotype
chromosomal rearrangements
chromothripsis
<i>MED12</i> mutations
Online Access:https://www.mdpi.com/2227-9059/9/12/1777

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https://www.mdpi.com/2227-9059/9/12/1777

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