Metformin is associated with improved clinical outcomes in patients with melanoma: a retrospective, multi-institutional study

Metformin is associated with improved clinical outcomes in patients with melanoma: a retrospective, multi-institutional study

BackgroundPre-clinical studies have shown that metformin reduces intratumoral hypoxia, improves T-cell function, and increases sensitivity to PD-1 blockade, and metformin exposure has been associated with improved clinical outcomes in various types of cancer. However, the impact of this drug in diab...

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Bibliographic Details
Main Authors: Ryan C. Augustin, Ziyu Huang, Fei Ding, Shuyan Zhai, Jennifer McArdle, Anthony Santisi, Michael Davis, Cindy Sander, Diwakar Davar, John M. Kirkwood, Greg M. Delgoffe, Allison Betof Warner, Yana G. Najjar
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Oncology
Subjects:
tumor microenvironment (TME)
melanoma
checkpoint blockade
oxidative phosphorylation
tumor infiltrating lymphocyte
progression-free survival
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1075823/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2023.1075823/full

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