Genome sequences of human cytomegalovirus strain TB40/E variants propagated in fibroblasts and epithelial cells

Genome sequences of human cytomegalovirus strain TB40/E variants propagated in fibroblasts and epithelial cells

Abstract The advent of whole genome sequencing has revealed that common laboratory strains of human cytomegalovirus (HCMV) have major genetic deficiencies resulting from serial passage in fibroblasts. In particular, tropism for epithelial and endothelial cells is lost due to mutations disrupting gen...

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Bibliographic Details
Main Authors: Ahmed Al Qaffas, Salvatore Camiolo, Mai Vo, Alexis Aguiar, Amine Ourahmane, Myrna Sorono, Andrew J. Davison, Michael A. McVoy, Laura Hertel
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Virology Journal
Subjects:
Human cytomegalovirus
Epithelial cell adaptation
PacBio
Whole genome sequence
TB40/E
UL122
Online Access:https://doi.org/10.1186/s12985-021-01583-3

Internet

https://doi.org/10.1186/s12985-021-01583-3

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