In vivo generation of human CD19‐CAR T cells results in B‐cell depletion and signs of cytokine release syndrome

In vivo generation of human CD19‐CAR T cells results in B‐cell depletion and signs of cytokine release syndrome

Abstract Chimeric antigen receptor (CAR) T cells brought substantial benefit to patients with B‐cell malignancies. Notwithstanding, CAR T‐cell manufacturing requires complex procedures impeding the broad supply chain. Here, we provide evidence that human CD19‐CAR T cells can be generated directly in...

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Bibliographic Details
Main Authors: Anett Pfeiffer, Frederic B Thalheimer, Sylvia Hartmann, Annika M Frank, Ruben R Bender, Simon Danisch, Caroline Costa, Winfried S Wels, Ute Modlich, Renata Stripecke, Els Verhoeyen, Christian J Buchholz
Format: Article
Language:English
Published: Springer Nature 2018-11-01
Series:EMBO Molecular Medicine
Subjects:
cytokine release syndrome
gene delivery
humanized mouse
T‐cell targeting
Online Access:https://doi.org/10.15252/emmm.201809158

Internet

https://doi.org/10.15252/emmm.201809158

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