An Investigation for Large Volume, Focal Blood-Brain Barrier Disruption with High-Frequency Pulsed Electric Fields

An Investigation for Large Volume, Focal Blood-Brain Barrier Disruption with High-Frequency Pulsed Electric Fields

The treatment of CNS disorders suffers from the inability to deliver large therapeutic agents to the brain parenchyma due to protection from the blood-brain barrier (BBB). Herein, we investigated high-frequency pulsed electric field (HF-PEF) therapy of various pulse widths and interphase delays for...

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Bibliographic Details
Main Authors: Melvin F. Lorenzo, Sabrina N. Campelo, Julio P. Arroyo, Kenneth N. Aycock, Jonathan Hinckley, Christopher B. Arena, John H. Rossmeisl, Rafael V. Davalos
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Pharmaceuticals
Subjects:
blood-brain barrier disruption
electroporation
finite element methods
Gadolinium
Evans blue dye
T1-weighted MRI
Online Access:https://www.mdpi.com/1424-8247/14/12/1333

Internet

https://www.mdpi.com/1424-8247/14/12/1333

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