An Investigation for Large Volume, Focal Blood-Brain Barrier Disruption with High-Frequency Pulsed Electric Fields
The treatment of CNS disorders suffers from the inability to deliver large therapeutic agents to the brain parenchyma due to protection from the blood-brain barrier (BBB). Herein, we investigated high-frequency pulsed electric field (HF-PEF) therapy of various pulse widths and interphase delays for...
Main Authors: | Melvin F. Lorenzo, Sabrina N. Campelo, Julio P. Arroyo, Kenneth N. Aycock, Jonathan Hinckley, Christopher B. Arena, John H. Rossmeisl, Rafael V. Davalos |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-12-01
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Series: | Pharmaceuticals |
Subjects: | |
Online Access: | https://www.mdpi.com/1424-8247/14/12/1333 |
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