Grpel2 maintains cardiomyocyte survival in diabetic cardiomyopathy through DLST-mediated mitochondrial dysfunction: a proof-of-concept study

Grpel2 maintains cardiomyocyte survival in diabetic cardiomyopathy through DLST-mediated mitochondrial dysfunction: a proof-of-concept study

Abstract Background Diabetic cardiomyopathy (DCM) has been considered as a major threat to health in individuals with diabetes. GrpE-like 2 (Grpel2), a nucleotide exchange factor, has been shown to regulate mitochondrial import process to maintain mitochondrial homeostasis. However, the effect and m...

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Bibliographic Details
Main Authors: Rongjin Yang, Xiaomeng Zhang, Yunyun Zhang, Yingfan Wang, Man Li, Yuancui Meng, Jianbang Wang, Xue Wen, Jun Yu, Pan Chang
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Journal of Translational Medicine
Subjects:
Diabetic cardiomyopathy
DLST
Grpel2
Mitochondrial dysfunction
Nr2f6
Online Access:https://doi.org/10.1186/s12967-023-04049-y

Internet

https://doi.org/10.1186/s12967-023-04049-y

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