Rotavirus NSP1 Inhibits Type I and Type III Interferon Induction

Rotavirus NSP1 Inhibits Type I and Type III Interferon Induction

Type I interferons (IFNs) are produced by most cells in response to virus infection and stimulate a program of anti-viral gene expression in neighboring cells to suppress virus replication. Type III IFNs have similar properties, however their effects are limited to epithelial cells at mucosal surfac...

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Bibliographic Details
Main Authors: Gennaro Iaconis, Ben Jackson, Kay Childs, Mark Boyce, Stephen Goodbourn, Neil Blake, Miren Iturriza-Gomara, Julian Seago
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Viruses
Subjects:
rotavirus
type I interferon
type III interferon
NSP1
IRF-1
IRF-3
Online Access:https://www.mdpi.com/1999-4915/13/4/589

Internet

https://www.mdpi.com/1999-4915/13/4/589

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