Transient Blockade of Type I Interferon Signalling Promotes Replication of Dengue Virus Strain D2Y98P in Adult Wild-Type Mice

Dengue virus serotypes 1 to 4 (DENV1–4) place nearly half the global population at risk of infection and the licenced tetravalent dengue vaccine fails to protect individuals who have not previously been exposed to DENV. The development of intervention strategies had long been hampered by the lack of...

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Bibliographic Details
Main Authors: Lucas Wilken, Sonja Stelz, Chittappen Kandiyil Prajeeth, Guus F. Rimmelzwaan
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Viruses
Subjects:
Online Access:https://www.mdpi.com/1999-4915/15/4/814