A Hybrid Model to Predict Formulation Dependent Granule Growth in a Bi-Component Wet Granulation Process

A Hybrid Model to Predict Formulation Dependent Granule Growth in a Bi-Component Wet Granulation Process

In this study, a hybrid modeling framework was developed for predicting size distribution and content uniformity of granules in a bi-component wet granulation system with components of differing hydrophobicities. Two bi-component formulations, (1) ibuprofen-USP and micro-crystalline cellulose and (2...

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Bibliographic Details
Main Authors: Indu Muthancheri, Rohit Ramachandran
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Pharmaceutics
Subjects:
wet granulation
multicomponent
population balance model
content uniformity
Online Access:https://www.mdpi.com/1999-4923/13/12/2063

Internet

https://www.mdpi.com/1999-4923/13/12/2063

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