Platycodon grandiflorum Triggers Antitumor Immunity by Restricting PD-1 Expression of CD8+ T Cells in Local Tumor Microenvironment

Platycodon grandiflorum Triggers Antitumor Immunity by Restricting PD-1 Expression of CD8+ T Cells in Local Tumor Microenvironment

In the tumor microenvironment (TME), the activation of programmed death-1 (PD-1)–programmed death ligand-1 (PD-L1) pathway is one of the main signals of immune escape and tumor deterioration. Clinically, the application of monoclonal antibodies slows down the progression of various malignancies and...

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Bibliographic Details
Main Authors: Ruijie Yang, Tianli Pei, Ruifei Huang, Yue Xiao, Jiangna Yan, Jinglin Zhu, Chunli Zheng, Wei Xiao, Chao Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Pharmacology
Subjects:
Platycodon grandiflorum
systems pharmacology
CD8+ T cells
tumor microenvironment
VEGF-A–VEGFR2
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.774440/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.774440/full

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