Pregnane X Receptor‒4β‐Hydroxycholesterol Axis in the Regulation of Overweight‐ and Obesity‐Induced Hypertension

Pregnane X Receptor‒4β‐Hydroxycholesterol Axis in the Regulation of Overweight‐ and Obesity‐Induced Hypertension

Background Mechanisms mediating hypertensive effects of overweight and obesity have not been fully elucidated. We showed previously that activation of pregnane X receptor (PXR) by rifampicin elevates 24‐hour blood pressure (BP) and plasma 4β‐hydroxycholesterol (4βHC), agonist for liver X receptor (L...

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Bibliographic Details
Main Authors: Roosa Rahunen, Outi Kummu, Vesa Koivukangas, Heidi Hautajärvi, Jukka Hakkola, Jaana Rysä, Janne Hukkanen
Format: Article
Language:English
Published: Wiley 2022-03-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
4β‐hydroxycholesterol
blood pressure
liver X receptor
obesity
pregnane X receptor
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.121.023492

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.121.023492

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