Diverse roles of the metal binding domains and transport mechanism of copper transporting P-type ATPases

Diverse roles of the metal binding domains and transport mechanism of copper transporting P-type ATPases

Abstract Copper transporting P-type (P1B-1-) ATPases are essential for cellular homeostasis. Nonetheless, the E1-E1P-E2P-E2 states mechanism of P1B-1-ATPases remains poorly understood. In particular, the role of the intrinsic metal binding domains (MBDs) is enigmatic. Here, four cryo-EM structures a...

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Bibliographic Details
Main Authors: Zongxin Guo, Fredrik Orädd, Viktoria Bågenholm, Christina Grønberg, Jian Feng Ma, Peter Ott, Yong Wang, Magnus Andersson, Per Amstrup Pedersen, Kaituo Wang, Pontus Gourdon
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-47001-4

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https://doi.org/10.1038/s41467-024-47001-4

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