Prevention of Wogonin on Colorectal Cancer Tumorigenesis by Regulating p53 Nuclear Translocation

Prevention of Wogonin on Colorectal Cancer Tumorigenesis by Regulating p53 Nuclear Translocation

The tumor suppressor protein p53 plays an important role in the development and progression of colon cancer, and the subcellular organelle localization directly affects its function. Wogonin (5,7-dihydroxy-8-methoxyflavone), a mono-flavonoid extracted from root of Scutellaria baicalensis Georgi, pos...

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Bibliographic Details
Main Authors: Qian Feng, Haojia Wang, Jiaying Pang, Liyan Ji, Jiada Han, Ying Wang, Xiaoxiao Qi, Zhongqiu Liu, Linlin Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Pharmacology
Subjects:
wogonin
colorectal cancer
p53 nuclear translocation
endoplasmic reticulum stress
apoptosis
autophagy
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01356/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01356/full

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