The Deubiquitylase USP4 Interacts with the Water Channel AQP2 to Modulate Its Apical Membrane Accumulation and Cellular Abundance

The Deubiquitylase USP4 Interacts with the Water Channel AQP2 to Modulate Its Apical Membrane Accumulation and Cellular Abundance

Aquaporin 2 (AQP2) mediates the osmotic water permeability of the kidney collecting duct in response to arginine vasopressin (VP) and is essential for body water homeostasis. VP effects on AQP2 occur via long-term alterations in AQP2 abundance and short-term changes in AQP2 localization. Several of...

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Bibliographic Details
Main Authors: Sathish K. Murali, Takwa S. Aroankins, Hanne B. Moeller, Robert A. Fenton
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Cells
Subjects:
water transport
NDI
aquaporin
ubiquitylation
post-translational modification
Online Access:https://www.mdpi.com/2073-4409/8/3/265

Internet

https://www.mdpi.com/2073-4409/8/3/265

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