Lysosomal cathepsins act in concert with Gasdermin-D during NAIP/NLRC4-dependent IL-1β secretion

Lysosomal cathepsins act in concert with Gasdermin-D during NAIP/NLRC4-dependent IL-1β secretion

Abstract The NAIP/NLRC4 inflammasome is classically associated with the detection of bacterial invasion to the cytosol. However, recent studies have demonstrated that NAIP/NLRC4 is also activated in non-bacterial infections, and in sterile inflammation. Moreover, in addition to the well-established...

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Bibliographic Details
Main Authors: Laura Migliari Branco, Marcelo Pires Amaral, Henning Boekhoff, Ana Beatriz Figueiredo de Lima, Ingrid Sancho Farias, Silvia Lucena Lage, Gustavo José Silva Pereira, Bernardo Simões Franklin, Karina Ramalho Bortoluci
Format: Article
Language:English
Published: Nature Publishing Group 2022-12-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05476-3

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https://doi.org/10.1038/s41419-022-05476-3

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