MET amplification identified by next-generation sequencing and its clinical relevance for MET inhibitors

MET amplification identified by next-generation sequencing and its clinical relevance for MET inhibitors

Abstract Background MET amplification plays an important role in the development of non-small-cell lung cancer (NSCLC) either de novo or in resistance to epidermal growth factor receptor tyrosine–kinase inhibitor (EGFR-TKI) settings. Fluorescence in situ hybridization (FISH) is the standard method f...

Full description

Bibliographic Details
Main Authors: Lun-Xi Peng, Guang-Ling Jie, An-Na Li, Si-Yang Liu, Hao Sun, Mei-Mei Zheng, Jia-Ying Zhou, Jia-Tao Zhang, Xu-Chao Zhang, Qing Zhou, Wen-Zhao Zhong, Jin-Ji Yang, Hai-Yan Tu, Jian Su, Hong-Hong Yan, Yi-Long Wu
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Experimental Hematology & Oncology
Subjects:
FISH-NGS
MET amplification
Predictive factors
Survival benefits
Online Access:https://doi.org/10.1186/s40164-021-00245-y

Internet

https://doi.org/10.1186/s40164-021-00245-y

Similar Items