Adenoviruses using the cancer marker EphA2 as a receptor in vitro and in vivo by genetic ligand insertion into different capsid scaffolds.

Adenoviruses using the cancer marker EphA2 as a receptor in vitro and in vivo by genetic ligand insertion into different capsid scaffolds.

Adenoviral gene therapy and oncolysis would critically benefit from targeted cell entry by genetically modified capsids. This requires both the ablation of native adenovirus tropism and the identification of ligands that remain functional in virus context. Here, we establish cell type-specific entry...

Full description

Bibliographic Details
Main Authors: Michael Behr, Johanna K Kaufmann, Patrick Ketzer, Sarah Engelhardt, Martin Mück-Häusl, Pamela M Okun, Gabriele Petersen, Frank Neipel, Jessica C Hassel, Anja Ehrhardt, Alexander H Enk, Dirk M Nettelbeck
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3997477?pdf=render

Internet

http://europepmc.org/articles/PMC3997477?pdf=render

Similar Items