Transfer of H2O2 from Mitochondria to the endoplasmic reticulum via Aquaporin-11

Transfer of H2O2 from Mitochondria to the endoplasmic reticulum via Aquaporin-11

Some aquaporins (AQPs) can transport H2O2 across membranes, allowing redox signals to proceed in and between cells. Unlike other peroxiporins, human AQP11 is an endoplasmic reticulum (ER)-resident that can conduit H2O2 to the cytosol. Here, we show that silencing Ero1α, an ER flavoenzyme that genera...

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Bibliographic Details
Main Authors: Ilaria Sorrentino, Mauro Galli, Iria Medraño-Fernandez, Roberto Sitia
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Redox Biology
Subjects:
Hydrogen peroxide
Redox homeostasis
Interorganellar crosstalk/ peroxiporin
Complex III
Mitochondrial-associated membranes
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722001823

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http://www.sciencedirect.com/science/article/pii/S2213231722001823

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