Evaluation of Radiation Sensitivity Differences in Mouse Liver Tumor Organoids Using CRISPR/Cas9-Mediated Gene Mutation

Evaluation of Radiation Sensitivity Differences in Mouse Liver Tumor Organoids Using CRISPR/Cas9-Mediated Gene Mutation

Background To assess the radiosensitivity of liver tumors harboring different genetic mutations, mouse liver tumors were generated in vivo through the hydrodynamic injection of clustered regularly interspaced short palindromic repeat/caspase 9 (CRISPR/Cas9) constructs encoding single-guide RNAs (sgR...

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Main Authors: Wan Jeon MD, Se Yeon Jung PhD, Chae Young Lee PhD, Won-Tae Kim PhD, Hyun Kim PhD, Kyoung Won Jang PhD, Heuijin Lim PhD, Manwoo Lee PhD, Dong Hyeok Jeong PhD, Sung Dae Kim PhD, In Ah Kim PhD, MD, Si Ho Choi PhD, Tae Gen Son PhD, Kyung Su Kim PhD, MD
Format: Article
Language:English
Published: SAGE Publishing 2023-03-01
Series:Technology in Cancer Research & Treatment
Online Access:https://doi.org/10.1177/15330338231165125

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https://doi.org/10.1177/15330338231165125

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