Feedback Inhibition of the Rag GTPase GAP Complex Lst4-Lst7 Safeguards TORC1 from Hyperactivation by Amino Acid Signals

Feedback Inhibition of the Rag GTPase GAP Complex Lst4-Lst7 Safeguards TORC1 from Hyperactivation by Amino Acid Signals

Amino acids stimulate the eukaryotic target of rapamycin complex 1 (TORC1), and hence growth, through the Rag GTPases and their regulators. Among these, the yeast Lst4-Lst7 Rag GTPase GAP complex clusters, as we previously reported, at the vacuolar membrane upon amino acid starvation. In response to...

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Bibliographic Details
Main Authors: Marie-Pierre Péli-Gulli, Serena Raucci, Zehan Hu, Jörn Dengjel, Claudio De Virgilio
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Cell Reports
Subjects:
target of rapamycin complex 1
TORC1
Rag GTPases
Lst4-Lst7 GAP complex
amino acid signaling
growth control
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717308896

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http://www.sciencedirect.com/science/article/pii/S2211124717308896

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