Characterization and regulation of cell cycle-independent noncanonical gene targeting

Abstract Homology-dependent targeted DNA integration, generally referred to as gene targeting, provides a powerful tool for precise genome modification; however, its fundamental mechanisms remain poorly understood in human cells. Here we reveal a noncanonical gene targeting mechanism that does not r...

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Bibliographic Details
Main Authors: Shinta Saito, Noritaka Adachi
Format: Article
Language:English
Published: Nature Portfolio 2024-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-49385-9