SAXS analysis of a soluble cytosolic NgBR construct including extracellular and transmembrane domains.

SAXS analysis of a soluble cytosolic NgBR construct including extracellular and transmembrane domains.

The Nogo-B receptor (NgBR) is involved in oncogenic Ras signaling through directly binding to farnesylated Ras. It recruits farnesylated Ras to the non-lipid-raft membrane for interaction with downstream effectors. However, the cytosolic domain of NgBR itself is only partially folded. The lack of se...

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Bibliographic Details
Main Authors: Joshua Holcomb, Maysaa Doughan, Nicholas Spellmon, Brianne Lewis, Emerson Perry, Yingxue Zhang, Lindsey Nico, Junmei Wan, Srinivas Chakravarthy, Weifeng Shang, Qing Miao, Timothy Stemmler, Zhe Yang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5773207?pdf=render

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http://europepmc.org/articles/PMC5773207?pdf=render

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