A promising mRNA vaccine derived from the JN.1 spike protein confers protective immunity against multiple emerged Omicron variants

A promising mRNA vaccine derived from the JN.1 spike protein confers protective immunity against multiple emerged Omicron variants

Abstract Despite the declared end of the COVID-19 pandemic, SARS-CoV-2 continues to evolve, with emerging JN.1-derived subvariants (e.g., KP.2, KP.3) compromising the efficacy of current XBB.1.5-based vaccines. To address this, we developed an mRNA vaccine encoding the full-length spike protein of J...

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Bibliographic Details
Main Authors: Danyi Ao, Dandan Peng, Cai He, Chunjun Ye, Weiqi Hong, Xiya Huang, Yishan Lu, Jie Shi, Yu Zhang, Jian Liu, Xiawei Wei, Yuquan Wei
Format: Article
Language:English
Published: Springer 2025-03-01
Series:Molecular Biomedicine
Subjects:
SARS-CoV-2
JN.1 variant
mRNA vaccine
Heterologous vaccination
Recombinant protein vaccine
Immune response
Online Access:https://doi.org/10.1186/s43556-025-00258-7

Internet

https://doi.org/10.1186/s43556-025-00258-7

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