Influence of intestinal microbial metabolites on the abscopal effect after radiation therapy combined with immune checkpoint inhibitors

Influence of intestinal microbial metabolites on the abscopal effect after radiation therapy combined with immune checkpoint inhibitors

Background: Most clinical studies failed to elicit a strong antitumor immune response and subsequent systemic tumor regression after radiation therapy (RT), even in combination with the immune checkpoint inhibitors (ICI) anti-CTLA4 or anti-PD1. Mechanistically, type I interferon (IFN-I) activation i...

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Bibliographic Details
Main Authors: Hannah Felchle, Julia Gissibl, Laura Lansink Rotgerink, Sophie M. Nefzger, Caroline N. Walther, Vincent R. Timnik, Stephanie E. Combs, Julius C. Fischer
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Clinical and Translational Radiation Oncology
Subjects:
Abscopal effect
Immune checkpoint inhibition
Intestinal microbiota
Type I Interferon
Bacterial metabolites
Online Access:http://www.sciencedirect.com/science/article/pii/S2405630824000351

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http://www.sciencedirect.com/science/article/pii/S2405630824000351

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