The combinatory effect of sinusoidal electromagnetic field and VEGF promotes osteogenesis and angiogenesis of mesenchymal stem cell-laden PCL/HA implants in a rat subcritical cranial defect

The combinatory effect of sinusoidal electromagnetic field and VEGF promotes osteogenesis and angiogenesis of mesenchymal stem cell-laden PCL/HA implants in a rat subcritical cranial defect

Abstract Background Restoration of massive bone defects remains a huge challenge for orthopedic surgeons. Insufficient vascularization and slow bone regeneration limited the application of tissue engineering in bone defect. The effect of electromagnetic field (EMF) on bone defect has been reported f...

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Bibliographic Details
Main Authors: Jingyuan Chen, Chang Tu, Xiangyu Tang, Hao Li, Jiyuan Yan, Yongzhuang Ma, Hua Wu, Chaoxu Liu
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Stem Cell Research & Therapy
Subjects:
Bone tissue engineering
Osteogenesis
Vascularization
Sinusoidal electromagnetic fields
Mesenchymal stem cell
Online Access:https://doi.org/10.1186/s13287-019-1464-x

Internet

https://doi.org/10.1186/s13287-019-1464-x

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