Design and optimization of DPC-crosslinked HPβCD nanosponges for entrectinib oral delivery: formulation, characterization, and pharmacokinetic studies

Design and optimization of DPC-crosslinked HPβCD nanosponges for entrectinib oral delivery: formulation, characterization, and pharmacokinetic studies

Abstract Background In advanced or metastatic cancers characterized by specific genetic alterations, heightened growth and resistance to conventional therapies are common. Targeted treatments like entrectinib (ENT) precisely inhibit aberrant signaling pathways, potentially enhancing outcomes. The ob...

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Bibliographic Details
Main Authors: Konda Sri Chaya Reddy, Darna Bhikshapathi
Format: Article
Language:English
Published: SpringerOpen 2024-08-01
Series:Future Journal of Pharmaceutical Sciences
Subjects:
Box–Behnken design
Cross-linker
Hydroxypropyl-β-cyclodextrin
Solubility
Entrectinib
Diphenyl carbonate
Online Access:https://doi.org/10.1186/s43094-024-00680-8

Internet

https://doi.org/10.1186/s43094-024-00680-8

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