Design and optimization of DPC-crosslinked HPβCD nanosponges for entrectinib oral delivery: formulation, characterization, and pharmacokinetic studies

Design and optimization of DPC-crosslinked HPβCD nanosponges for entrectinib oral delivery: formulation, characterization, and pharmacokinetic studies

Abstract Background In advanced or metastatic cancers characterized by specific genetic alterations, heightened growth and resistance to conventional therapies are common. Targeted treatments like entrectinib (ENT) precisely inhibit aberrant signaling pathways, potentially enhancing outcomes. The ob...

Ful tanımlama

Detaylı Bibliyografya
Asıl Yazarlar: Konda Sri Chaya Reddy, Darna Bhikshapathi
Materyal Türü: Makale
Dil:English
Baskı/Yayın Bilgisi: SpringerOpen 2024-08-01
Seri Bilgileri:Future Journal of Pharmaceutical Sciences
Konular:
Box–Behnken design
Cross-linker
Hydroxypropyl-β-cyclodextrin
Solubility
Entrectinib
Diphenyl carbonate
Online Erişim:https://doi.org/10.1186/s43094-024-00680-8

Internet

https://doi.org/10.1186/s43094-024-00680-8

Benzer Materyaller