Design and optimization of DPC-crosslinked HPβCD nanosponges for entrectinib oral delivery: formulation, characterization, and pharmacokinetic studies

Abstract Background In advanced or metastatic cancers characterized by specific genetic alterations, heightened growth and resistance to conventional therapies are common. Targeted treatments like entrectinib (ENT) precisely inhibit aberrant signaling pathways, potentially enhancing outcomes. The ob...

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Những tác giả chính: Konda Sri Chaya Reddy, Darna Bhikshapathi
Định dạng: Bài viết
Ngôn ngữ:English
Được phát hành: SpringerOpen 2024-08-01
Loạt:Future Journal of Pharmaceutical Sciences
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Truy cập trực tuyến:https://doi.org/10.1186/s43094-024-00680-8