Coupling antitoxins and blue/white screening with parAB/resolvase mutation as a strategy for Salmonella spp. plasmid curing

Coupling antitoxins and blue/white screening with parAB/resolvase mutation as a strategy for Salmonella spp. plasmid curing

ABSTRACT Despite the dissemination of multidrug resistance plasmids, including those carrying virulence genes in Salmonella spp., efficient plasmid curing tools are lacking. Plasmid partitioning and multimer resolution systems are attractive targets for plasmid cure. However, plasmid curing strategi...

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Bibliographic Details
Main Authors: Dereje D. Gudeta, Shaohua Zhao, Nesreen Aljahdali, Steven L. Foley
Format: Article
Language:English
Published: American Society for Microbiology 2024-11-01
Series:Microbiology Spectrum
Subjects:
plasmid curing
parA mutation
toxin/antitoxin systems
blue white screening
plasmid stability
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01220-24

Internet

https://journals.asm.org/doi/10.1128/spectrum.01220-24

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