Common mouse models of tauopathy reflect early but not late human disease

Common mouse models of tauopathy reflect early but not late human disease

Abstract Background Mouse models that overexpress human mutant Tau (P301S and P301L) are commonly used in preclinical studies of Alzheimer’s Disease (AD) and while several drugs showed therapeutic effects in these mice, they were ineffective in humans. This leads to the question to which extent the...

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Bibliographic Details
Main Authors: Kathrin Wenger, Arthur Viode, Christoph N. Schlaffner, Patrick van Zalm, Long Cheng, Tammy Dellovade, Xavier Langlois, Anthony Bannon, Rui Chang, Theresa R. Connors, Derek Oakley, Bernhard Renard, Juri Rappsilber, Bradley Hyman, Hanno Steen, Judith A. Steen
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer’s disease
Human Tau
Post-translational modifications
Protein aggregation
Tauopathy
Mouse model
Online Access:https://doi.org/10.1186/s13024-023-00601-y

Internet

https://doi.org/10.1186/s13024-023-00601-y

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