Studies in a Murine Model Confirm the Safety of Griffithsin and Advocate Its Further Development as a Microbicide Targeting HIV-1 and Other Enveloped Viruses

Studies in a Murine Model Confirm the Safety of Griffithsin and Advocate Its Further Development as a Microbicide Targeting HIV-1 and Other Enveloped Viruses

Griffithsin (GRFT), a lectin from Griffithsia species, inhibits human immunodeficiency virus-1 (HIV-1) replication at sub-nanomolar concentrations, with limited cellular toxicity. However, in vivo safety of GRFT is not fully understood, especially following parenteral administration. We first assess...

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Bibliographic Details
Main Authors: Joseph Calvin Kouokam, Amanda B. Lasnik, Kenneth E. Palmer
Format: Article
Language:English
Published: MDPI AG 2016-11-01
Series:Viruses
Subjects:
Griffithsin
HIV
safety
mouse model
microbicide
peripheral blood mononuclear cells (PBMCs)
Online Access:http://www.mdpi.com/1999-4915/8/11/311

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http://www.mdpi.com/1999-4915/8/11/311

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